Sethuraman Panchanathan, the Indian-American Director of the National Science Foundation (NSF), has stepped down from his position following reported pressure from the Trump administration to reduce the NSF’s budget and workforce. Alleged disagreements over budget allocations and diversity, equity, and inclusion (DEI) initiatives are believed to have contributed to Panchanathan’s decision to resign. In his resignation, Panchanathan stressed the significance of upholding the United States’ leadership in scientific research and fostering partnerships with Indian educational and research institutions. His departure marks a significant development in the realm of science and technology, particularly concerning US-India collaborations.